China Cardiac Markers


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China Cardiac Markers Myoglobin Test Kit (Fluorescence Immunoassay) Application: It is suitable for quantitative detection of myoglobin (Myo) in human serum, plasma or whole blood in vitro. Package: 1 test/kit, 5 tests/kit, 10 tests/kit, 25 tests/kit, 50 tests/kit. Clinical Significance 1. A good indicator for judging reinfarction 2. Early negative exclusion index for acute myocardial infarction 3. Effective indicators for assessing myocardial infarction reperfusion 4. Blood and urine myoglobin levels also increase in renal insufficiency, burns, alcoholism, and diabetic acidosis Components The kit consists of myoglobin detection reagent card, detection buffer, ID card, instruction manual, desiccant, and aluminum foil bag. Myoglobin (myoglobin, Mb) Myoglobin (Mb) is a small molecule protein composed of globin combined with heme. It can reversibly combine with oxygen and play the role of transporting and storing oxygen in muscle cells. A variety of clinical factors can cause skeletal muscle and cardiac muscle damage, changes in cell membrane integrity, muscle cell content into the extracellular fluid and circulatory system, resulting in elevated serum myoglobin levels. In addition, dynamic monitoring of changes in serum myoglobin content can predict the severity and prognosis of various clinical diseases. Myoglobin (Mb) is an intracellular pigment protein that exists in the cytoplasm of skeletal muscle and cardiac muscle tissue, contains iron porphyrin and is homologous to hemoglobin. It contains a polypeptide chain composed of 153 amino acid residues and a Heme prosthetic group. Mb can store O2 in muscle and release it rapidly when tissue is deprived of oxygen, and it is also involved in the process of glucose oxidation. The binding capacity of Mb to oxygen is between that of hemoglobin and cytochrome oxidase, which can help muscle cells to transport oxygen to mitochondria, regulate and buffer intracellular O2 levels when the body's muscle activity increases, and promote the transportation of O2 in cells; Mb also It is related to NO chemical reaction and scavenging. Molecular biology techniques such as gene targeting can further reveal and understand the mechanism of Mb transport of O2. The factors that cause skeletal muscle and myocardial damage include trauma, infection, drugs, immune diseases and endocrine and metabolic disorders, which are then dissolved, the integrity of the cell membrane changes, and the contents of muscle cells enter the extracellular fluid and blood circulation system. Resulting in the increase of serum Mb content, this process involves many pathophysiological mechanisms such as activation of phospholipase A2, mitochondrial dysfunction, continuous contraction of muscle cells, and oxidative stress caused by free radicals. Elevated serum Mb levels result from skeletal muscle and/or cardiomyocyte injury (lysis/necrosis) release into the blood circulation. Serum Mb 70ng/ml, and its level varies with age, sex, and race. Mb can be detected in serum in the early stage after myocardial infarction, and the peak time (1-2 hours) is earlier than that of creatine kinase (CK). Mb has a small molecular weight and is easily excreted in urine. After reperfusion therapy, serum Mb levels increase rapidly and have been used as a useful indicator to assess the success of reperfusion therapy or the size of myocardial infarction. However, due to the short half-life of Mb (15 minutes), serum Mb levels are not stable 6 to 12 hours after the onset of chest pain. Increased, it helps to rule out acute myocardial infarction. At the same time, because the duration of elevated Mb levels is short-lived (24 hours), Mb measurement is helpful to observe the presence or absence of reinfarction or infarct expansion in the course of acute myocardial infarction. Frequent increases in Mb levels suggest that the original myocardial infarction is still ongoing. It should be pointed out that Mb is also a component of skeletal muscle and lacks specificity, so the clinical value of a series of Mb determinations after myocardial infarction is relatively limited. For patients with chest discomfort and non-diagnostic ECG manifestations, Mb measurement alone cannot be used to diagnose acute myocardial infarction within the first 4 to 8 hours of onset, and more specific tests, such as CK-MB or cardiac troponin, are needed.China Cardiac Markers website:http://www.modaivds.com/all-poct-products/cardiac-markers/

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